You don't really need to work with ball pythons - in the end, they are still a wild animal. Mine are handled about once a week, maybe 5 minutes at a time, when cleaning. Every now and then I'll want a longer handling session, it's just a matter of deciding who I want to visit with.
All of mine are pretty docile for the most part. Of coure, being snakes, they all have their bad days - nothing that more handling would have changed though.