Soak your snake in a large bowl of warm [NOT HOT] water for 20 mins or longer You may have to hold it in there the whole time. Dunk its head under a few times [be careful] for 5-8 seconds [mites liketo stay near the head / eyes / under head. The soaking should drowned most of the mites. After you do that dry him off but don't put him back in his cage. Your going to want to clean out the entire thing. I use mite off and it works pretty well.