I havent had much experience with it before but Ive asked this before and the answer was no, there arent really any handling restrictions. Of course you should still allow it to have a week or so to settle in and get a meal or two under its belt probably I believe. I could be wrong, hopefully someone will come in and correct me or verify. Im going on the safe side here. Other than that, I know you can keep them out for hours of handling without stressing them like BPs. Part of the reason why I wanted a boa so bad.