What kind of chameleon is it? And pics would greatly help. From what it sounds like, this could be an eye infection. Do you notice any mucusy discharge in his eyes, and does he keep his eyes closed most of the time? My chameleon looked like that when he had his eye infection, as well as the swollen/puffyness. Either way, if anything is wrong with a chameleons eyes (any animals eye really) you need to take him to the vet. Without it, you will have to hand feed the chameleon, which will then quickly loose the elasticity and muscle tone of his tongue, which later on may lead to tongue amputation, which is what my vet told me when I came in to see him. Hope that helps