I do it all the time 4 hour drive from FSU to Orlando. I just empty the water to a minimum put the tank in the back seat because it takes up the whole back seat. And just drive with A/C or windows down on the front windows. THe tank wont shake as much if it is directly on the seat. My snake doesnt seem to mind usually just chills in his hide the whole ride.

*I have a 36x18x12 Glass tank*