It's your pet, handle it if you want to. One of the reason I'm so drawn to snakes as pets is because I like to handle them. I just like the way they feel. Whether or not they start feeling too stressed out if you handle them is for you to decide through observation and experience and you gain experience by handling your python regularily and being alert to the way he behaves in varying circumstances. So handle him as often as you wish. As long as you learn something about your animal each time you handle it, you'll know you're doing it right.