It would be a miracle if ever my grandmother changed. She hates anything without fur. I just got a leo today and she freaked out when I had it out of the cage to show my mom.
Now my mom loves lizards, especially beardies, but she doesn't like snakes. Thankfully she's not the "Oh no, its going to bite me. Its such a horrible creature." kind of person. She actually asked me to take Zim out tonight so she could see it. She won't touch or hold him, but she likes to look at him.
My brother refuses to even be in the same house if I have the snake out. (and he's 18)