How long have you had her?mine got slightly cranky the other day after she poop'd in the tank,then she ate a mouse yesterday for the first time since i got her almost 2 months ago.maybe this is why she is a little cranky.maybe im wrong as im new to pythons but its just a thaught.or as you say maybe she is getting ready to shed,as iv read that sometimes they do not like being handled when they are shedding their skin.