Well I do think they will eventually have an adverse reaction. Remember snake's don't always react in ways we understand or have reactions that are obvious and immediate (like a human shivering for instance when suddenly exposed to a drop in temps). Your snake may not "freak out" but it may over time and exposed to a lot of cooler room temps outside it's home, develop illnesses and/or a depressed immune system due to stress, etc. I think it's all about balance and putting the snake's needs first. If your home is very chilly then avoid exposing the snake to it more than necessary or keep the snake in contact with your warm skin. Don't sit in a drafty room or keep the snake out for hours....just common sense things like that really.