I only have two snakes.

Currently my Ball is handled everyday, sometimes for 10 minutes, sometimes hes out for a few hours. He's very docile. Except after feedings for about 2 days.

My corn is held every few days, as he is still quite twitchy, but we've ben gradually working for longer and longer periods outside the cage, and I can now even put him on a flat surface without him zooming off right away.

That said, it can take a lot of time to get a nervous snake to calm down. But persistance pays off if you want to handle them. Start my putting something in the cage that smells like you (a washcloth that you carried around for awhile has worked quite well). Also start reaching in to the cage and touching them for a few minutes. If you are nervous about bites, wear gloves, and don't get all twitchy and jumpy if they do try to nip you, that just makes them more nervous. Then slowly start taking them out for a few mintues, but stay in a quiet area with no loud noises. Eventually you can start taking them out for longer periods, and even moving about the house.

The worst thing you can do is rush them. If you start something too fast, let them settle. Regular handling at a regular time should help.

My bp hangs from my shirt while I go about the house and loves to sit beside keyboard while I'm typing.