How much does she weigh? I've noticed our females go through a distinct change in attitude, feeding, reaction to handling, etc. around 800 or 900 grams and it lasts till they are a good 1,200 grams or more. Seems a sort of teenage thing (Adam calls it teenage angst) as they start maturing into adult females. Maybe this is what's up with your female. As always though, of course watch her health and doublecheck all your husbandry to make sure that there isn't any underlying issues there that are causing her change of behaviour.