We usually try to wait until we see either of our snakes poke her head out of a hide, or being a little active, so mid to late evenings is when that happens...

Although on Sunday, we handled and then fed Cleo late afternoon since we had her out already to clean her tank; we decided to go ahead weigh/fed/etc. after putting her back in so we wouldn't pester her again later that day. She had that "Wha-what are you doing? I was sleeeeping! *yawn*" attitude when we first got her out, hehe...