handle and feed her whatever time of the day you like. it really doesnt matter. when i handle my snakes i do it for 15-20 minutes 1-2 times a day. just dont handle on feeding day and for atleast 2 day after she's eaten.

you can start feeding every week if you like. feed her prey items that are a little smaller then her at the thickest part of her body.

i prefer feeding my snakes in their tubs because they can hunt for their prey from their hides and the stress of moving them before feeding could cause them to not eat. ball pythons are pretty shy snakes.

if you feed live responsibly you will have no problems. just make sure the rat doesnt bite the snake and you'll be fine. you can feed live or dead, its your personal preference.