Standard vet care such as shots ,worm check, heartworm & flea prevenative such as frontline Run me about 275.00 per year. That includes the rabie tag. If your dog has short hair the grooming can be so easy to do yourself. Learning to cut nails is also a simple task.

Remember the spay or nueter surgery is a one time cost and well worth it if you are wanting a pet.
If you do maint. care on your dog and use a leash when out, to avoid accidents vet bills can be kept to a min.. The 275 was actually more than my bill was this year.
Quality food is a must. For a 25 lb french bulldog and a 95 lb. borzoi it cost me about 10 dollars a week for a high performance diet.
Also about every 3 years the dog may need a teeth cleaning. Dental chew toys will cut the number of those visits. My borzoi is six and has never required a cleaning. I brush his teeth and do a little dental scraping. Caution! A dog that isn't used to someone messing with his teeth will not allow you to scrap.
I show my dogs so maint. has always been the key to cutting cost. Any size dog is affordable if you practice reg. maint. The giant breeds are more prone to extremely expensive medical problems.
The best thing to remember is to buy from a reputable breeder that will put a guarantee of some degree as far as hereditary problems.

Sorry for the lengthy post