Ive always found it real easy to tell the difference between males and females (on rodents) ... Males have a couple things hanging by their tails that look like tires.
Mice are EXTREMELY smelly. Youll want to make sure that their enclosure is very well ventilated. They also like to climb and chew ... If there is a hole in a plastic enclosure you will soon have mice running all around the house. In addition to them breeding like crazy they also find any excuse to kill each other or their litters.
Bryan