From my experience, the males will help the females with the litters. All of my males lay on top of the babies to keep them warm when momma eats, and helps make a nest, and they def. guard them from harm (my wandering hands)! *I* suggest leaving them together, unless you get 3 litters all at once. I'm pretty sure 3 litters and 4 mice in a 10 gallon is too much going on, but i could be wrong.
Sometimes, the female or the male will eath the babies, and usually for a reason. If mom is stressed, or if its her first litter, she may eat them. If the house is too crowded, or there is competition for food or water, she may eat them. Sometimes just one or 2 will be eating because of illness or general weakness.