My 5.5' boa I handle/feed/give shots to by myself.

My 7' 4" 21lb female I probably should have someone with me to deal with. I never do anything with her unless someone else is home. Yesterday I took her downstairs soaked her in the tub and gave her a shot by myself.

I've held a 12' burm by myself (but with others around), but I wouldn't recommend you doing anything with an animal of that size with no one else around. A boa won't get that big though..