i hold my snakes every day. it used to be for like 10-15 minutes at a time but now i keep them out for 20-25 minutes at a time. i have had my bp for a year now and he is completely mellow when out. the only days i don't hold my snakes are the dyas after they eat then after that they are out again from my expeirience it doesnt stress my snakes at all. my blood has a great feeding response(about all do) and my bp has it's moments but still when on feed my bp eats like a savage. so as long as the handling sessions aren't too long then handling your snake frequently is fine IMO

Brian