Handling new BP for feeding and weighing

[Homebody]

My question is what's the best way to get her out of the enclosure both to weigh her and completely replace her substrate?

If you're able to target your BP out of its enclosure, that is what you should do. Grabbing her out of her enclosure may be contributing to her increasing shyness. Here a link to a video where I target my Children's python out for weighing.