Will my python ever recover?

[Bogertophis]

Her appetite is great, always has been. She has never refused a meal.

I was wondering if her metabolism changed from the antibiotics and from feeding her larger rats.

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Antibiotics have a very negative effect on the digestive system- true for snakes as well as humans & others. Most of us find that adding probiotics to their meals after a course of antibiotics to be very helpful, since antibiotics destroy the good gut bacteria along with whatever infection they're intended to cure. Without adequate gut bacteria, the digestion is poor with nutrients NOT being fully absorbed. There are various products designed to replenish the gut bacteria in snakes: Nutribac & Bene-Bac have both been around a long time, & there are likely other options by now as well, for which you can search for what's available in your area. Never give these WHILE a snake is on antibiotics- only AFTER the course of treatment is done.