Will my python ever recover?

[Bogertophis]

I would only put probiotics IN the oral cavity- much falls off the fur, or changes the taste, or "gets sticky" (if rodents are damp). And personally I'd keep giving them for a while- they shouldn't hurt anything, & might help, so why not? As previously discussed, long antibiotic therapy does a number on a snake's digestion (or ours, for that matter, or most any other animal). The fact that she seems underweight or is losing a bit of weight is a good reason to assume she hasn't been getting all she could have from her meals with better digestion (ie. WITH probiotics).

Since you just over-fed her, you'll probably need to wait a bit longer to feed again- I'd guess a good 2 weeks. You truly don't need an exact feeding schedule- feeding every 10 days is just an approximation, since humans think in terms of schedules & like to keep track. In the wild, remember there is no such thing as a schedule- & some keepers only feed after they see a snake expel waste (that tends to space meals further apart, not what you'd want to be doing right now) or when a snake is visibly hungry (which often ends up being too much food, since just like us, they don't always know when to quit).

Point is, it's not critical as long as your snake is digesting well & not regurgitating. With those large rats, a MUCH better idea would have been to feed only one at a time, & at a slightly reduced interval- maybe 8-9 days- for best digestion. Large rats have thick fur & are much harder to digest.

I'm in the "camp" that never weighs food & very rarely weighs my snakes. But since you do- you don't need a precise feeding schedule- IF a snake is losing weight, feed a little more, or feed a little sooner, or both; IF a snake is gaining weight, slow that down a little. Don't make any huge sudden changes- just watch the results & make small changes based on what you see & what's needed. And remember that both snakes & humans are considered healthier when slightly underweight, as opposed to being overweight. I suspect that's where your vet's recommendation is coming from- vets are used to seeing over-fed pets.

bcr229 has a ton of experience with these large snakes- I'd take their word for it (feeding 5%) ANY day. And no, it can't "hurt anything".