Well, you & your vet did the right thing, checking bloodwork & fecal. If your vet didn't hazard a guess, I don't think I should either- but some animals, just like some humans, live much longer than others- different genes, variable exposure to things in life, who knows? What kind of python are we talking about here, anyway? Maybe she has poor digestion (for whatever reason)- if you don't digest food well, your body lacks the nutrition to support muscle mass & all. But you said her stools are "normal"? (not oily or especially stinky? and no parasites?)
Sure sounds to me like SOMETHING'S going wrong- metabolically.The way you describe her does sound like a few snakes I've had- but they were well in their 20's- very old. I assume you're sure about her age? In humans, unintended weight loss can signal things like cancer- but that often includes feeling poorly with a poor appetite. A GOOD appetite with weight loss suggests internal parasites (food sharing) to me, or inadequate digestive enzymes. (You could try adding digestive enzymes to her food- but ask your vet to recommend a specific type/brand).
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