Not a lot of info given, but if your boa is 2 years old, it can go several months without eating.
My advice, unless there are signs of illness, is not to feed the animal for at least another month more.
The hissing sounds defensive, but that may not be the case.
I'm just giving you basic info, not a definite blueprint or plan that will solve the issues.
Try quail on the next feed.
For reference, I haven't fed my boa since last October. I have friends here that have animals the same age as your animal and they practice a seasonal break in feeding.
Your snake isn't hungry or it has a potential health issue.
The striking and hissing during the feeding attempt is rejection of the prey and a sign to leave it alone.









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