I thaw in water. When I first started keeping, I thawed in the refrigerator overnight (18 - 24 hrs). My snake never got sick from it. He did refuse sometimes, but he was an adult BP. They do that.
I stopped mostly because I kept forgetting to move the feeders from the freezer to the refrigerator the night before. I would then have to thaw in water. I, ultimately, decided it was just simpler to keep doing it that way.