I've got five short tail pythons ranging from 6-9 years old and never had an RI issue, my cage humidity usually sits around 60 and I have a room humidifier for the cold season but they regularly flood the cages with pee or by playing in the water dish and turn it into a swamp. Keep your temps stable and steady and humidity high enough for health and they'll be fine. Some of them shed badly no matter how high or low the humidity is though.
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