Typically they spend a lot of time during the day in a hide so as long as you avoid moving right outside of the hide entrance you should be fine. I will lift the hides off them if I need to be up close to that area so they know it's not feeding time or anything as well. They loose the ambush position they had and need to reevaluate the situation.
If it is a male you usually don't have to worry about them getting more bitey later. Females may sometimes if they are ovulating in breeding season, but it's different for each snake. One of mine is an absolute sweetheart no matter what's going on.
Ball pythons can be very heavy bodied so lifting them out with the hook can be detrimental to them. As mentioned above, it can be helpful in some applications like the gentle touch or slight lift to help you get a hand under them.
For one of my most defensive ones, for a bit I used a plastic plate as a distraction. She would lock in on the large plate, I would move it over her and gently rest it on her and reach around to pick her up from the back. As soon as the big plate got too close she would go from defensive strike pose to defensive hunkered down.
Eventually I was able to get her body tells down well enough to switch to using my hand. That was I could assertively use my open palmed hand to get her from one phase to the other and lift from the back.
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