You should hold off on handling until your spotted python is eating. When you do handle your snake, you'll want to avoid stressing her out and getting bit. To avoid stressing your snake out, I advise you to use choice-based handling approach. Lori Torrini has a great instruction video here. Choice-base handling reduces the stress of handling by allowing your snake to choose whether and to what extent it's handled. This is particularly important for you because stressing your snake will reduce the likelihood that she'll eat.
To avoid getting bitten while working in the enclosure, I advise wearing gloves. Your snake will react to the warmth and movement of your hands. Wearing gloves keeps you from triggering her predatory behavior. I have a Children's python. I used to ball up my fist and let him sniff me before working in his enclosure. That worked pretty well, but I had to do it over and over again every time I put my hand in. Other times, I thought it was safe because I didn't see him only to have him strike from nowhere. Wearing gloves is simpler.