I can't help you with the genetics, but some snakes can be challenging to transition to pre-killed prey (either fresh-killed "f/k" or frozen-thawed "f/t") while others don't seem to matter, or even appreciate that they can just gulp them down. Ball pythons, as you know, tend to rely on their heat-sensing pits, so many find that p/k prey needs to have some lifelike warmth. Rarely, some snakes will never change though, especially when they're adults & have been eating only live prey for years, so if you're concerned about that, it might be wise to test this snake before you agree to take it on.
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