Cincinnati to Anchorage is 65 hours on the road. That's 4-8 days depending on how you end up driving it, longer if Gramma has to stop at every Tim Hortons you pass.
FedEx apparently can do overnight to AK:
https://ball-pythons.net/forums/show...ight-to-alaska
FedEx charge on a 12" cube box is a bit less than $200 from OH to AK. You get the shipping label from these excellent folks:
https://shipyourreptiles.com/
I'm willing to bet there is more than $200 worth of hassle in arranging for two CITES permits (one from US, one from Canada) and customs fees and import taxes, but I've never arranged permits. You might get in touch with Sam at Reptile Express (good company) to see if he would simply line up permits for you.
https://www.reptileexpress.com/
To ship, you'd need someone on the OH end to hold the snake and then pack it up for you, and then some way to get yourself to the FedEx ship center in AK to pick it up (shipping animals door to door nowdays isn't a good option).
Delta Dash (airport to airport) might be an option, but I couldn't find a flight on their website to give you an idea of what that would take. Calling them might yield some info.
It is likely six on one hand and a half-dozen on the other. Many people would probably feel more comfortable with the snake in the vehicle with them, but planning ahead for possible big problems (breakdown, accident, weather, etc) would make me want to think hard about shipping.
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