Help! Sudden behavior switch

[Bogertophis]

He sounds like either he's in pain or some sort of digestive discomfort. Bear in mind that antibiotics kill all the good bacteria indiscriminately along with the bad, & with poor digestion, maybe his stomach feels bad. Were the antibiotics given injectable type? Oral antibiotics don't do much in snakes, because they're cold blooded & don't absorb them properly from the gut, so most likely they just end up making things worse- especially how the snake "feels". Keep in mind that animals cannot always distinguish between "hunger pangs" & an upset stomach due to causes other than hunger.

After giving a snake antibiotics, may I suggest you add reptile probiotics to his food to help his gut bacteria return to normal- so he can better digest his food. Either "Bene-Bac" or "Nutribac".

When you took him to the vet, I hope you took a fresh stool sample for the vet to check? If not, do so- intestinal worms could be sharing his food- that could explain all his symptoms too, actually. Especially if the pet shop he came from fed him live mice (that's where they catch "worms" from- live prey).

I've never used Reptaid- but I notice they don't show a snake on the label. Anyway, I doubt that it did much either for or against him.

Rosy boas (especially males more than females) do often go off food in fall/winter- sometimes for months, especially if they felt the cool enough in their home to be aware of the seasonal change. (I've raised rosy boas for many years, though I no longer breed them- & I still have just 1 rosy boa among my pet snakes.) What are the temperatures in his home- tell me more about his living arrangements.
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He mostly sounds hungry to me- what are you feeding him? how much, how often? PLEASE try giving him probiotics with his meals.

Years ago, I used to offer advice & help to a nearby nature museum that had rosy boas & other local snakes. The behavior you're seeing with yours reminds me of one of theirs- also used for public "meet & greets". You had to pay close attention because sometimes the snake would sort of push his nose into the hand that was holding him, here & there, before deciding "gee, maybe I CAN eat this?" & biting! Silly snake! Hey, some are smarter than others- what can I say? And some make better goodwill ambassadors than others, but since yours was "well-behaved" prior to all this, I think there's a good chance that he'll regain that once he is (A) fed more, with probiotics added, and (B) handled a little more regularly.

*****When snakes bite, there's a reason. I think that most likely he is confusing stomach irritation (from the meds given) with hunger pangs. *****
(What antibiotic was he given? injectable, or? Keep in mind, while they may be necessary at times, they may not be without harm too.)

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Never take it "personal" when a snake tries to bite you thru the glass- they're going after motion, & usually hoping it's edible. They need your scent & touch to identify you- most snakes aren't that visually oriented. Also, snakes cannot really hear- so your talking makes you feel good, but all your snake gets -at the most- is some bass note vibrations on the glass, which further peaks his interest in eating if he's thinking about food & seeing a little motion out there...

I'd say there's a good chance you can avoid another expensive vet visit if you try the probiotics as I suggested, OR at the most, you can drop off a stool sample to be checked (since the vet already SAW this snake). Okay? All the best- let us know if this helps?

I hope the vet you saw has plenty of snake experience? If not, this may help for future reference: https://arav.site-ym.com/search/custom.asp?id=3661