Personally, I'd waterproof it for sure. Sooner or later, your snake will do a big juicy excretion, or dump the water bowl, & I won't envy you in cleaning up the leak from the enclosure.
In fact, if the moisture contacts some electrical things, it may also be a safety issue. Take that little bit of time, always, to be on the safe side, so you're more likely to have many disaster-free years enjoying your pets.
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