We can't tell you how long it "takes" for a new snake to get comfortable with you & your handling- they're all different, just like we are, & the experiences they may have had before they moved in with you aren't all the same either. It's just up to us to be calm & patient & do our best to read their reactions (their "body language") & take it from there. Don't push a frightened snake too much, or they may stop eating. But most of the time, patience & empathy will pay off- your snake will learn you won't harm them & they'll relax.