I know this is a really old thread but I wanted to chime in with something we just learned with one of our males.

We only have 5 ball pythons. 1 mature male and 2 mature females. Our adult male used to be a crazy good eater. Would take whatever you put in front of him. All of a sudden he totally went off feed. Husbandry was on spot. temps humidity, etc.

He went months of us offering every 2 weeks. He would take a look at the rat then quickly proceed to head out of his terrarium toward the females. He started loosing weight and we started worrying about him. We decided to try moving him to another room away from the females. he is back to eating like a champ again. Pretty much as soon as you open the cage and start the rat down toward him he hits it.

So maybe it is rare but it does happen.