Some people like scaleless some don't same with hairless cats. Scaleless BP are actually not that trendy many people prefer their BP with scales and this shows when you look at the market.
Obviously it naturally occurs it was not engineered with strange experiments.
As for their health scaless cornsnakes are doing fine and have been around for quite some time.
Ball pythons well it's best to hear from someone that works with them, sure there was some controversy at first but a lot of it came from how the projects was originally handled, the secrecy and the conspiracy theories however there are no longer any secret.
Anyway here are some info they are a little higher maintenance but again so are hairless cats.
Personally I would love to have a scaleless snake however I would be leaning toward a cornsnake or a ratsnake they just look more appealing to me.
Bottom line you like scaleless buy one you don't then don't same applies for every single mutation out there from Banana to Spider to Pied to Champagne to Scaleless