Hello, welcome to the forum and the wonderful world of snake keeping!!
The first thing I picked up on was that you're talking about upsizing prey, which is a good idea, but...
A) you don't want to jump too quickly, let her body acclimate to smalls a few times before jumping to mediums.
B) she's a pretty small female (based on her age, I'd be questioning if she is in fact a female) and even larger females never need bigger than a medium rat. So no need to upsize to larges, they'll be way too big for her. As for now, even two small rats is too much. It's a lot for her system to handle, especially considering her previous feeding schedule.
As for the handling, hold off until she's eating regularly. That means no handling until she has eaten 3 consecutive meals without refusal. That means if she refuses, the clock starts over.
She's stressed and you can't blame her. Be patient with her and give her time to acclimate.