Only if you sealed it tightly & never opened it. If it's a styro-foam box, you can poke a few tiny holes in it, or just open a few times a day. As I noted during the ice
storm, I was replacing the jars of hot water about every 8-9 hours...that was just fine. Remember that snakes are shipped this way (generally no air holes in styro-
foam) & that can take anywhere from a day to a few days cross country. But an easy way to be sure is to put a tiny wad of tape under the edge of the lid, so it doesn't
quite seat all the way shut. That's what I did when I moved cross country with my snakes boxed up, & they were opened each night, handled a bit & given water.
Snakes travel quite well, as their needs are minimal.