New Ball Python just started hissing.

[Craiga 01453]

Thanks for your help. I feed on Monday nights so I was handling him on Thursday Friday and Saturdays. Letting him have 2 days to digest and leaving him alone the day before he eats. What would you guys recommend as far as handling frequency? He has never struck at me just hissing. Dont wanna stress the little guy out.

Between 5 and 10 minutes. Its usually just me in there with him.

Ok, I would just slow down a little bit with handling for a bit til he gets more comfortable. Once you build a trust for one another and he's got a bit more size on him he'll likely chill right out.
Instead of three consecutive handling days maybe cut out Friday so he's got a day in between to just chill.