The only problem (as long as you aren't over-feeding) is when you wait too long between the prey items fed. Once the digestion gets going on the first item,
giving a second one can result in a nasty smelly regurgitation of both items, wasting them both & necessitating a couple weeks rest (NO FOOD) for the snake
while their stomach recuperates & rebuilds the necessary digestive enzymes. Feeding too soon after such an event (regurg.) can set off another one & even
lead to unintended dehydration & death of the snake.
So as long as the 2 items (or even 3-!) add up to the size/amount of the ONE they'd normally be fed, just make sure they are all fed one after another with no
long gaps in time between them. Some snakes will do this easily, others may not. A few snakes refuse more than one item, even when small...I have an old
corn snake (about 20 years old) who won't eat more than one at a time. A "long gap" is an hour or more...it screws up their digestion to keep throwing more
food into their stomach...their enzymes aren't up to the task of dealing with the mix of partly-digested and UN-digested items simultaneously.
In the past I had some delightful gopher & bull snakes: they are a good example of snakes that, in the wild, go right into rodent burrows and consume the
entire family of rodents. I've always raised my own rodents (& have MORE than enough) and when I kept these snakes, I re-enacted that by giving one of them a number of smaller rodents....you'd be amazed at what they'll happily pack away.
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