Ideally, yes. I've (knock on wood) never had any mites or other illnesses in any of my snakes, so fortunately haven't had to treat any. But, from all I've read, it's much easier (and cheaper) to treat one than all of them. And, as keepers, it's our responsibility to keep our animals healthy. So following proper quarantine is a must.
As for handling, I highly recommend following the "3 meal rule". Basically, no handling until the snake has eaten three consecutive meals without refusal.
Handling is solely for us. So it's important to put their health above our desire to handle.
These snakes live 20+ years in captivity, so there will be plenty of time f9r handling.