Does he do it when he's startled or upset? It took us awhile as new owners to figure out that ours was hissing and not wheezing. We adopted a very nervous and somewhat aggressive snake and we noticed it if we touched her, opened the door of the enclosure, or anytime she was just being really grumpy and wanted to be left alone she would hiss.
If you think he's really wheezing though, try to catch it on video and show your vet to make sure he's okay.
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