Just make sure he has adequate hides, temps, humidity, fresh water, and food. Aside from that not much else you can do. They are living animals and will not be the same all the time. As long as he is not overly stressed out from too much handling he should be fine. Most snakes and especially ball pythons can be "huffy" when you go to pick them up but usually calm down once you pick them up. Just be confident and don't make it worse by being hesitant when you go to pick him up. hopefully he calms down soon for you.