the vibrations might spook him b/c it's how they "hear" but TBH it's hard to tell esp. if you're vacuuming it's during the day and it's hiding/sleeping. they get over it. u should be fine unless he starts displaying signs of stress after vacuuming. u gotta vacuum and there's no way around it unless u move his enclosure somewhere where vacuuming isn't really required like hardwood floors or whatever.