I've had water condense on the plastic wrap and start to sag in the middle, this resulted in water drops hitting the top of my eggs. Did it effect hatch rate? No. Did it annoy me: Yes. I don't bother with the Press and Seal now-its primary purpose is to keep humidity trapped inside. I incubate with no substrate-just a layer of heated water on the bottom with the eggs sitting above on plastic crate above in a closed bin. I open every bin (for a few seconds) every week to check the eggs, and every few days when they are approaching the hatch date-this provides air exchange.