That is quite relative.
A large amount of urine will make a larger spot. That said, it contains the urine far better then the other substrates. You will have to spot clean a larger area for a larger snake. To me that is still worth it, because I don't like my animals to lay on urine soaked paper or aspen, not to speak of the smell that permeates the whole room.
You could always just test it out in one cage.
I know of one person that mixes Reptile Prime with Repti Chip for the larger snakes. It dries out the wet Repti Chip quicker, plus it keeps the snake from moving the fluffier Reptile Prime around to much. It works better at containing messes then Repti Chip alone.
I mixed it for a while simply to use up my left over Repti Chip. I like the Reptile Prime by itself, better, but with larger snakes it may be an option? Just try different things in one cage before you commit totally![]()