I disinfect enclosures and decor once a month. I disinfect water dishes weekly. I use chlorhexidine (generic Nolvasan) for my monthly and I use anti-bacterial dish soap for my weekly. All wood gets dipped in chlorhexidine, rinsed and then baked in the oven at 300 degrees for 15 minutes.
I use Aspen for substrate and change it out every two weeks. On top of spot cleaning when required.