Always in the enclosure. Less stress, much less chance of regurgitation from being moved/stress, and snakes don't really learn that hands=food unless you've been handling rats without washing your hands. If my guy is acting hungry- peeking out of a hide, tongue flicking, S-shaped curl, then I don't try and pick him up. Its all about knowing your snake and their body language and habits
No cage is too large - nature is the best template - a snoot can't be booped too much
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