The only determined bite I've received was after an egregious error I made. I was still new to herping and my only ball python had gone off food that winter for the first time. That early spring day she seemed hungry again so I thawed her rat. I was holding her and talking on the phone, and then I brought her over to "sniff" her almost ready rat to "keep her enthusiasm up" (when I learn a lesson the hard way, I go ALL in.)
As I walked away with her, she just calmy turned her head around and latched onto my knuckle with her whole ravenous face. Then she threw some coils around my hand for good measure and gave it her all. Yes, it hurt.
My voice went up an octave as I kept chatting on the phone. I tried to start peeling her off. She bit harder so I stopped. I tried running her under a neutral stream of tap water. My purple finger paid for that, too. In the end, I just waited until she was finished. 6 minutes later I got my finger back none the worse for wear besides like 40 or so pin pricks.
Lessons I've learned: don't chill with super hungry snakes, don't chill when rats are a'thawin', it hurts to get a feed bite, but not so much that I've purchased any mouthwash for the occasion since, and you're all but healed up the next day.
If your snake bites maybe out of hunger, try using hand sanitizer before holding and a few days after food. Good luck!

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