This was one of my concerns when I started planning my projects as well. From the research I did, I chose to go nothing more than one generation breeding back, or even one brother to sister, before breeding back in new bloodlines. The thing is, with ball pythons, it doesn’t have near the same problems as it does with mammals. With that said, I personally still don’t feel comfortable doing more than one generation or even see the need to unless your dealing with a one of a kind new morph and have no other options.