Put snake in pillow case/snake bag, secure tightly, place in well padded box not much larger than the snake. I keep a thermometer probe in the box to keep an eye on temps. Don't leave in direct sun.
If it's a two day drive give it a temporary tub/enclosure when you stop for the night to drink some water and such. Place back in the bag, secure, put it back in its box and finish the drive. Basically you're just packing your animal as though you were shipping it. There's a few good threads on the subject on here if you search for them
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