With an enclosure that big, if you don't go bio-active for your substrate you are going to be spending an arm and a leg changing out mulch when it gets past the point of no return. I really recommend going with a good san/dirt/DG/Peat mixture, it gives good structure, holds humidity, allows them to burrow, and is a great host to all the little critters that will maintain the tank for you.
http://www.savannahmonitor.co/ Click on the link to the right of this page, it discusses bio-active in depth. The setup in bio-active for the Sav I found to be almost identical for the Tegu.
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